Back

/ Contact

Martine COHEN-SOLAL
martine.cohen-solal@inserm.fr

Thomas FUNCK-BRENTANO
thomas.funck-brentano@inserm.fr

Hôpital Lariboisière
2, rue Ambroise Paré
75457 Paris Cedex 10

Back

Bone

The « Bone » team at Bioscar integrates clinical and translational research with the clinical management of patients with prevalent bone disorders (primary and secondary osteoporosis) and rare bone fragility conditions.
It provides an opportunity to explore the mechanisms of bone fragility by analyzing key molecules involved in bone remodeling and the mode of action of drugs directly implicated in current or innovative treatments.
The unit operates a platform for the characterization of bone diseases, which is utilized for patient care as well as for preclinical and cellular models. The team’s research is marked by a constant interplay between clinical data, including patient cohorts and biobanks of serum and tissue, which fosters academic and industrial studies, and the evaluation of molecular effects on cellular, tissue, and whole-organism models.

/ Expertises

1. Characterization of determinants of bone fragility using specialized equipment for human cohorts or preclinical models

  • Biochemical markers of bone remodeling
  • Bone mineral density (Lunar and Faxitron bone densitometers)
  • Bone microarchitecture (Scanco HRpQCT high-resolution micro-CT scanner, Skyscan 1272 micro-CT scanner)
  • Bone tissue histology platform for non-decalcified samples (histomorphometry) or decalcified samples (immunohistochemistry and immunofluorescence), including single and multiplexed analyses (RNAscope and Basecope).
  • Cell models of bone formation or resorption (osteoblastic cell lines, primary human and murine osteoblasts and osteoclasts)
  • Transcriptomic analysis of human and murine blood and tissues
  • Serum and tissue biobank of patients with rare diseases

2. Bioscar and the Rheumatology Department are a center of expertise for rare bone diseases

They are designated as a reference center for rare skeletal and fibrous dysplasias under the auspices of the Oscar network, the Head and Neck network and the European Network for Rare Bone Diseases.
We analyze the skeletal and extraskeletal determinants of osteocondensing diseases (e.g., osteopetrosis and osteosclerosis), bone and joint collagenopathies (e.g., osteogenesis imperfecta and epiphyseal dysplasias), dystrophic pathologies (e.g., fibrous dysplasia), craniofacial disorders (e.g., cherubism), and mineral metabolism disorders (e.g., rickets and hypophosphatasia).

/ Faculty

Martine COHEN-SOLAL
MD, PhD
martine.cohen-solal@inserm.fr
Thomas FUNCK-BRENTANO
MD, PhD
thomas.funck-brentano@inserm.fr
Johann BEAUDREUIL
MD, PhD
johann.beaudreuil@inserm.fr
Amélie COUDERT
University lecturer
amelie.coudert@inserm.fr
François BRIAL
University lecturer
francois.brial@inserm.fr

Agnès OSTERTAG – Engineer researcher
Morgane BOURMAUD – Engineer
Mylène ZARKA – Engineer
Nathalie ANDROCLES – Engineer assistant
Pascale CHANTRENNE – Technician
Jacqueline FRANCISQUIN – Technician
Gwenaelle JAYAT – Technician
Maeva ROULLAT – Technician
Sylvie THOMASSEAU – Technician

Charlotte LOGIOU – PhD Student
Erika PALLADINO – PhD Student
Antoine BARBIER – M2

/ Selected Publications

View all our publications

Letter to the Editor: More on bone microarchitecture and volumetric BMD in men and women with PLS3 gene variants assessed with HR-pQCT.

J Bone Miner Res. 2025 Dec 15:zjaf192. doi: 10.1093/jbmr/zjaf192. PMID: 41396051

Vanjak A, Cohen-Solal M, Chapurlat R, Guggenbuhl P, Javier RM, Collet C, Funck-Brentano T.

Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis.

J Bone Miner Res. 2025 Oct 30:zjaf159. doi: 10.1093/jbmr/zjaf159. PMID: 41165785

Ostertag A, Léger B, Koumakis E, Fardellone P, Zarka M, Funck-Brentano T, Mabilleau G, Cohen-Solal M.

The bone phenotype associated with cherubism is independent of Caspase-1-dependent inflammasome activation in the mouse.

PLoS One. 2025 Feb 14;20(2):e0318826. doi: 10.1371/journal.pone.0318826. eCollection 2025.PMID: 39951467

Rabhi BV, Thomasseau S, Decrouy X, Cohen-Solal M, Deckert M, Coudert AE, Brial F.
Genetics and bone mineral density predict the fractures in adults with osteogenesis imperfecta: a prospective study.
J Clin Endocrinol Metab. 2024 Nov 8:dgae791. doi: 10.1210/clinem/dgae791. PMID: 39514768
Blandin C, Collet C, Ostertag A, Funck-Brentano T, Cohen-Solal M.
Osteopetrosis and related osteoclast disorders in adults: A review and knowledge gaps On behalf of the European calcified tissue society and ERN BOND.

Eur J Med Genet. 2024 Jun;69:104936.

Funck-Brentano T, Zillikens MC, Clunie G, Siggelkow H, Appelman-Dijkstra NM, Cohen-Solal M.
Osteoporosis and Fragility Fractures in Patients With Cirrhosis Evaluated for Liver Transplantation: Identification of High-Risk Patients Based on Computed Tomography at Evaluation.

Am J Gastroenterol. 2023 Nov 10.

Nachef C, Bousson V, Belmatoug N, Cohen-Solal M, Vilgrain V, Roux O, Francoz C, Durand F, Funck-Brentano T

WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis

2022 19;31(10):1622-1634. doi: 10.1093/hmg/ddab349. PMID: 34875064.

Caetano da Silva C, Edouard T, Fradin M, Aubert-Mucca M, Ricquebourg M, Raman R, Salles JP, Charon V, Guggenbuhl P, Muller M, Cohen-Solal M, Collet C. Hum Mol Genet.
Retour en haut