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Eric HAY
eric.hay@inserm.fr

Augustin LATOURTE
augustin.latourte@aphp.fr

Hôpital Lariboisière
2, rue Ambroise Paré
75457 Paris Cedex 10

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Osteoarthritis

Identify new molecules controlling osteo-articular destruction in an inflammatory or mechanical context

The osteoarthritis project is centered on the molecular mechanisms of catabolic mediators (IL6) and the regeneration (Lin28a) of the cartilage. These candidate molecules will be analyzed at the mechanistic cell and tissue levels will be and integrated using KO mice before and after induction of joint instability. This project led by P. Richette is funded by industrial credits

The second part will be focused on the regeneration of cartilage, in particular the mechanisms of cell reprogramming (Éric Hay). LIN28 is a post-transcriptional regulator of RNAs involved in pluripotency, differentiation and cell proliferation during development. For this purpose, mice with inducible conditional invalidation and overexpression of Lin28 will be subjected to experimental osteoarthritis. We will analyze the metabolic mechanisms at the origin of the programming. This project is supported by the Road network.

/ Expertises

  1. Murine models
  2. Clinical assesment and trials

/ Faculty

Eric HAY
University lecturer
eric.hay@inserm.fr
Augustin LATOURTE
HU

augustin.latourte@aphp.fr

Pascal RICHETTE
MD, PhD

pascal.richette@aphp.fr

François BRIAL
University lecturer
francois.brial@inserm.fr
Hang Korng EA
MD, PhD and Director
korng.ea@inserm.fr

Agnès OSTERTAG – Engineer researcher
Morgane BOURMAUD – Engineer
Mylène ZARKA – Engineer
Nathalie ANDROCLES – Engineer assistant
Pascale CHANTRENNE – Technician
Jacqueline FRANCISQUIN – Technician
Gwenaelle JAYAT – Technician
Maeva ROULLAT – Technician
Sylvie THOMASSEAU – Technician

Malorie COSSEZ-GUIGNE – PhD Student
Sana ABAGHDIR – M2

/ Selected Publications

View all our publications

SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase.
Dis. 2024 Nov 14;83(12):1781-1790.
Latourte A, Jaulerry S, Combier A, Cherifi C, Jouan Y, Grange T, Daligault J, Ea HK, Cohen-Solal M, Hay E, Richette P. Ann Rheum.
Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice.
Sci Adv. 2022 Aug 26 ;8(34):eabn3106.
Jouan Y, Bouchemla Z, Bardèche-Trystram B, Sana J, Andrique C, Ea HK, Richette P, Latourte A, Cohen-Solal M, Hay E.
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
Ann Rheum Dis. 2021 Mar;80(3):349-355.
Latourte A, Rat AC, Omorou A, Ngueyon-Sime W, Eymard F, Sellam J, Roux C, Ea HK, Cohen-Solal M, Bardin T, Beaudreuil J, Guillemin F, Richette P.
Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis.
Osteoarthritis Cartilage. 2021 Sep;29(9):1335-1345.
Cherifi C, Latourte A, Vettorazzi S, Tuckermann J, Provot S, Ea HK, Ledoux A, Casas J, Cuvillier O, Richette P, Ostertag A, Hay E, Cohen-Solal M.
Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial.
SCI. ADV. 2022. 8(34) doi : 10.1126/sciadv.abn3106
Richette P, Latourte A, Sellam J, Wendling D, Piperno M, Goupille P, Pers YM, Eymard F, Ottaviani S, Ornetti P, Flipo RM, Fautrel B, Peyr O, Bertola JP, Vicaut E, Chevalier X.
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