/ Contact
Dominique MODROWSKI
dominique.modrowski@inserm.fr
Hôpital Lariboisière
2, rue Ambroise Paré
75457 Paris Cedex 10
Tumor & micro environment
Bone metastasis and Biology of Bone Sarcomas are to study how bone factors and bone micro environment could contribute to bone metastasis.
Despite the improvement of surgery and the use of agressive chemotherapies, the survival rate of patients with bone sarcomas did not evolved for decades. Especially, the number of patients with metastases was not reduced. Our aim is to highlight new prognosis markers that could help to predict tumor progression and metastases and aslo therapeutic targets to treat disseminated osteosarcomas.
/ Expertises
- Role of hypoxia and hif-1alpha in skeletal development
- Role of bone environment in metastasis
- Osteoblast niches
- Cancer stem cells in osteosarcoma
/ Faculty
Agnès OSTERTAG – Engineer researcher
Morgane BOURMAUD – Engineer
Mylène ZARKA – Engineer
Sylvie THOMASSEAU – Technician
Morgane BOURMAUD – Engineer
Mylène ZARKA – Engineer
Sylvie THOMASSEAU – Technician
Mel GAVENS – PhD Student
/ Selected Publications
Cell Death Dis. 2022 Sep 24;13(9):819. doi: 10.1038/s41419-022-05244-3. PMID: 36153320; PMCID: PMC9509353.
Tchicaya-Bouanga J, Hung YJ, Schwartz JM, Yoon DJY, Chotard E, Marty C, Odri GA, de Pinieux G, Cohen-Solal M, Modrowski D
Cancers (Basel). 2022 Jan 12;14(2):360. doi: 10.3390/cancers14020360. PMID: 35053522; PMCID: PMC8774233.
Odri GA, Tchicaya-Bouanga J, Yoon DJY, Modrowski D.
JCI INSIGHT. 2018. 3(17) doi :10.1172/jci.insight.121225
Andrique, C, Morardet, L, Linares, LK, Cisse, MY, Merle, C, Chibon, F, Provot, S, Hay, E, Ea, HK,
Cohen-Solal, M, Modrowski, D.
Devignes C.S., Aslan Y., Brenot A., Devillers A., Schepers K., Fabre S., Chou J., Casbon A.J., Werb Z, and Provot S